The American scientist decodes HIV's genome atlas completely for the first time

The American scientist decodes HIV's genome atlas completely for the first time
But mysterious veil of danger that fatal HIV has been wrapping all the time. Its genome is complicated and elusive, not long-known, therefore it is extremely more difficult to want to develop medicine to the ill which captures AIDS. Recently, American scientist adopts a kind of new technology to get HIV's genome " The big picture " ,Decode the genome atlas of HIV completely for the first time.
HIV's structure is very complicated
This month Publish on the 6th >The magazine has issued this achievement . Professor Kevin of U.S.A. N.C. State university Weekes leads the group to adopt new technology to draw out HIV's picture " The big picture " ,Can observe the ribonucleic acid (RNA) Nucleotide, catenate structure and their association state.
Medical science of HIV is called completely " L Defective virus (HIV) of human immune system " ,It is a kind of RNA virus. All living beings and some virus depend on DNA (DNA) of the double-stranded structure Carry the hereditary information, but HIV relies on RNA of the structure of single strand to carry the hereditary information. Influenza virus, C-mode hepatitis virus and poliomyelitis and virus are the same, but their structure is not so complicated as HIV.
The new technology is drawn " L The big picture " R
Professor Weekes and his group adopts a new chemical method to call SHAPE, not only catch to the nucleotide of RNA but also shown shape and folding way of RNA chain.
RNA foldaway intricate three-dimensional structure of the structure of single strand, its information of code is decoded compared with being more difficult in DNA, judge function to the virus of each gene is more difficult. Researchers have imitated and analyzed some RNA genome of HIV successfully before this, this pair of HIV RNA genome which contains as many as ten thousand pieces of nucleotide is far from enough.
" This, as story that took a part for the whole, sometimes what you found is some not all truth of the things. So our technology is the whole structure of finding the gene as much as possible. " Professor Weekes says. Professor of U.S.A. Michigan university department of chemistry Hashemite shows too, though the picture got has lost some details, but can know the overall picture of the whole virus.
These decades, scientists in sum HIV " L Play hide-and-seek " . This research will help scientists to understand how RNA genome decide the lifespan of HIV, how to control HIV to infect the mankind, and how to proliferate rapidly. Because the drug effect against virus medicine correlates with arruance extent of virus genome, genome of HIV using the new technology to get " The big picture " Will help the researcher to make the more effective antiviral medicine.
Sound
" We can change the array of RNA by causing gene mutation, observe whether the virus reacts to this kind of change to some extent. If the change of the array causes the virus and be unable to proliferate normally, explaining some important information of forming the virus influences. "
---Thesis another author, little biologist Ronald Swan and Storm
" Because of this genetic atlas, the scientist is expected to reveal the activity situation of virus and some internal proteins of genetic structure, clarify their function. Say more extensively, this technology can help us to open the structure of the complicated gene of some virus, the system of more different virus, to that it has newer understanding how the virus act on the human body. " ---David of Manchester university Doctor full of trees of Rob
This research results " L It is a starting point but not ends " ,The therapeutic method of researching and developing AIDS still needs longer time and enormous efforts, but it is a great step stridden forward towards this goal to offer an overall genome atlas.
---U.S.A. >Magazine

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