Rare disease announces the ripe cells of new method can be changed into adult's stem cell

Rare disease announces the ripe cells of new method can be changed into adult's stem cell
Organizing the report on November 21 of network according to the American physicist, the researchers of Harvard Medical School and Harvard Faculty of Dentistry published on November 21>Write articles on the magazine to point out, through a kind of rare hereditary disease of simulation, they can let ripe cells be returned to adult's stem cell's state, this kind of stem cell that gets newly can divide into cells of different types, training wares and test which the animal carried on on one's body to all succeed.
Cell biologist, president of Harvard Faculty of Dentistry cloth Jorn and Allson of Harvard Medical School say, find newly it is significant in the fields of individualized medical treatment and organizational engineering.
Going on ossified bad disease (playboy) of fibrous hyperplasia It is a kind of rare inborn disabling disease, nearly there are 1000 patients in the whole world, its clinical manifestation will ossify to lead to the fact slowly the body becomes stiff for the patient's skeleton skin and soft connective tissue, there is no effective therapeutic method at present.
Harvard Medical School and Boston the intersection of shellfish and the intersection of Sri Lankan and Israel woman the intersection of executive officer and medical medical instructor of centre strange to find in beautiful in Damien, organize a different one with ordinary skeleton, FOP patient cartilage and bone of morbid state include biological mark of endothelial cell in the cell in the body. This let him produce a query, did the patient's cartilage and bone originate from endothelial cells?
U.S.A. strange to change variation gene to initiate FOP for normal endothelial cells with colleague. Out of people's expectation, endothelial cells are then transformed for a type of new cell, this kind of adult stem cell or the bone marrow whose cell can be split into bone, cartilage, muscle, fat even nerve cell fills the quality stem cell.
The further experiment finds, do not induce this kind of transition by mutant gene, researchers can use two kinds of particular proteins too ' Growth factor TGF-beta2 With BMP4) Any kind of China comes to train endothelial cells, the cell reciprocation of these proteins has imitated the function of the gene of making a variation, this has provided method of a more effective recombination cell for scientist. Later, researchers put these cells recombinated respectively and trained wares to neutralized on animals, it becomes a group of relevant organization types that they are developmental finally.
U.S.A. strange to show new cell these stem cell at all the same with fill quality among the bone marrow, it is very important to clarify this point, but potentiality and plasticity that they fill the quality stem cell while all possessing and similar to the bone marrow.
Allson claim the system getting strong to lie in this only one natural repetition of course, in this sense, with compare to the intersection of cell and method recombinated to go on while being other at present, its manual intervention is less.
Expert in the global FOP field, molecule medical professor Frederick and Kaplan of plastics of the medical college of Pennsylvania state university are a cooperator of this research too, he says, the new discovery lets people know how to make use of this course to make the extra skeleton that the patient needs badly for the first time.
U.S.A. strange to respond, claim with Allson, most direct to it employs to be organizational engineering and individualize medical field discovery these. The scientist believes, some day, it is accepted that the patient that transplants may extract one's own endothelial cells, then go on, recombinate, can long to become the intersection of organization and type that them need come on, use for, transplant then, and will not present the rejection. (Liu Xia )
|