U.S.A. has found one kind the essential _'s prevention and health care of albumen grows to pancreas cancer

U.S.A. has found one kind the essential _'s prevention and health care of albumen grows to pancreas cancer
American the intersection of Stanford University and medical college find one grow essential albumen to pancreas cancer, the expression of blocking this albumen can slow down or prevent little mouse's growth of tumour in the body, and make the cancer cell trained easier to be influenced by hypoxic condition taking place in entity's tumour. This research results are issued on the " cancer research " magazine published on February 1.
Researchers are called the connective tissue growth factors(CTGF) to one kind Albumen CCN2 last research,this albumen and health or there have something to do is growths unusual of connective tissue when disease react to damaging, also may correlate with growth of pancreas tumour, but its function produced is not yet very clear.
In fact, in one tumour that develop, soon until those express, compete for low the intersection of albumen and cell of competence cell these. On the contrary, it can not be unable to form tumour that CCN2 expresses the pancreas cancer cell inhibited from.
When the cancer cell is injected into animal's pancreas, researchers observed the similar result. Compared with expressing for the cancer cells of low-level CCN2, express tumour formed for cancer cell of high-level CCN2 and grow faster, shift more positively. The little mouse which has poured into high-level CCN2 cancer cells dies earlier too by contrast.
Researchers suspect whether CCN2 is guaranteeing tumour cells survived to contribute under the oxygen deficiency condition. If really so, perhaps can explain the manifestation while tumour grow of cancer cell that CCN2 expresses. They find, will block CCN2 to express in the pancreas cancer cell that is trained and will make the death that the cancer cell cause to oxygen deficiency much more sensitive. In addition, CCN2 expression in the human pancreas tumour sample is higher than other perimeter tissues, it seems expressed and concerned with with the other albumens which is short of oxygen cell that CCN2 expresses. Finally, the oxygen deficiency condition will initiate the pancreas cancer cell to produce CCN2.
A lot of other cell conditions can start CCN2 to express too, including the existence of CCN2. The activation of the other routes related to cancer can also increase it to express. As a result, a lot of incidents happening in a developing tumour produced a large amount of CCN2 just like storm, then lead to the fact tumour is grown and shifted rapidly.
Researcher say CCN2 inhibit already the obvious result has emerged among the little mouse experiments. They hope to combine antibody treatment with the standard treatment in the future, can produce very good curative effect too in treating the human patient's tumour.
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