What the whole people it will be U.S.A. " Strong to mend folic acid "
Because an associate professor of the intersection of Peking University and medical science department sees Chinese Government providing funds and mending the advertisement of folic acid at the gate of his home free, send an article and query the related departments on the net " Strong to mend folic acid " Method. According to him, most people have already got sufficient folic acid from the food, and high folic acid may promote the growth of the cancer cell, cause the increase that tumour has illness coming on. He says filled with indignationing: "It is our country can spend money recklessly, the stage letting everybody have disease? "In fact, China to recommend, mend folic acid now, have strong to mend folic acid. U.S.A. strong to mend folic acid, seem in these medical science department associate professor, this is poisoning. Say what so terrific folic acid him on earth then? Really so terrible?
1931, British while finding local poor women were pregnant when did research in India getting easy a kind of malignant anemia in Willes in Lucy in physiologist, there is a kind of nutrition factor that can prevent and treat this kind of disease in the yeast. This kind of factor is originally named " Willes' factor " . 10 years later, it is isolated from leaf of the spinach, is named folic acid for the first time.
Folic acid is a kind of B clan vitamin, it is the indispensable composition when the cell division formates DNA. If folic acid that take in too little in meal, to can reduce while being synthetic DNA, reduce cell division. All cells of the division will be influenced, but the influence that those cells split fast receive is more serious, for example the production of erythrocyte was reduced, presented anaemia.
That let folic acid enjoy great reputation was that one kind let nerve in charge of the inborn defect of the defect later. The human embryo has presented an area to call neural board during the third week, the middle of it sinks partly, the edge rises, form the neural pleat. The nerve pleat of both sides closes up the inside gradually, by about the 27th day, close and form the nerve to manage. Divide into brain and spinal after the neural tube.
If the nerve is in charge of without closing, it is in charge of the defect to present the nerve. This is one of the most common inborn defects seriously most too, in every 1000 neonates, 1~2 have nerve to in charge of the defect: Full of brain have development to be fine, the deformity have, survive in the same way almost; It is good to mostly the bone of backbone have no development, the spinal is stressed or exposed outside, ask the backbone to split. The backbone will present symptoms such as paralysing, incontinence of feces and urine, intelligence obstacle,etc. while splitting.
The emergence that the nerve is in charge of the defect relates to many kinds of factors. In the fifties last century, researchers noticed an important factor among them was malnutritive. In the population below the poverty line, the incidence that the nerve manages the defect is always higher. Moreover, the proportion that the baby becoming pregnant in winter and early spring suffers from the backbone and splits is higher, while becoming pregnant, is not mother apt to have fresh vegetables and fruit?
Having reached 1960 times, researchers make animal's experiment to find, it can cause the nerve to be in charge of the defect to lack folic acid. Begin to carry on research to people subsequently. All show in 1980 times and several clinical trials made at the beginning of 1990 times, folic acid of the previous and pregnant early supplementary high dosage in the pregnant woman is pregnant, can prevent the nerve from being in charge of the defect effectively, the incidence of letting the nerve in charge of the defect is reduced by 60% to 75%. Folic acid that pregnant woman take in quantity high, appear nerve in charge of to the lower risk have defect.
According to these results of study, the service department of U.S.A.'s public health proposed all women of child-bearing age take in 400 micrograms of folic acid every day in 1992. Folic acid widely exists in various food, the rich food containing folic acid includes dark green leaf vegetables, citrus, beans and the whole valley,etc.. Unfortunately, folic acid in the food is very unstable, while gathered in, stored, processed and cooked, over half of the folic acid activity will be lost. Folic acid is water soluble vitamin, easier to lose while poaching. Moreover, natural folic acid is difficult to be absorbed by the human body, only about 50% can be absorbed by the human body.
Take leaf vegetables that the folic acid content is supreme as examples, though the intersection of folic acid and content of them can be up to 160 micrograms 100 grams, but after considering the unstability of folic acid of food and but absorbability, want, take, could meet pregnant woman's requirement for folic acid by 1 the intersection of leaf and vegetables every day, this is obviously different to accomplish. So, the ones that talked to Peking University, associate professor are opposite, it is difficult for most people to get sufficient folic acid from the food. According to the estimation of United States Department of Agriculture, most American women of child-bearing age have 200 micrograms only from folic acid that is absorbed in the food every day.
Fortunately, mankind synthetic folic acid of success as far back as 1945. Synthetic folic acid is extremely stable, can store for a few years and does not lose the activity, nearly can 100% absorb by the human body. Preparation is much more reliable than to supplement folic acid by the meal to take folic acid. Though the doctors will all generally advise the pregnant woman to take folic acid preparations, that the nerve is in charge of the defect happened at the pregnant first month, pregnant woman know oneself to be already pregnant at this time, wait until, find pregnant to supplement folic acid to be right away too late. For avoid the situation, should supplement folic acid before being pregnant, have half the pregnancy unscheduled probably, for the sake of assurance, all women of child-bearing age should supplement folic acid preparations every day.
But combine importance that not every of women of child-bearing age knows folic acid, even know only a few people can insist on taking folic acid preparations every day. Add folic acid in food, let all the intersection of people and " strong to mend folic acid " It is the most thorough method. American food medicines administration bureau made the decision in 1996, required the grain products added a certain amount of synthetic folic acid since January of 1998 by force. Estimate according to addition level, each American and extra supplementary about 200 micrograms of folic acid every day, combine with from folic acid of other food intakes, can basically meet the requirements for folic acid of pregnant woman's body. Result very obvious, after not adding folic acid, implementing one year by force, American nerve in charge of the defective incidence lower by 26%. Canada took the same measure in 1998 too, the result was more obvious, the nerve was in charge of the defective incidence to reduce by 46%.
The whole people are strong may make some people's folic acid too high in intaking amount to mend folic acid, but say it is the sensationalism that high folic acid will cause the increase of tumour morbidity. Have not found what side effects folic acid has to take in too high at present. But high folic acid may interfere with the diagnosis to vitamin B12 deficiency disease. About 1/5 of the old persons lack vitamin B12, initial symptom is that anaemia appears. If folic acid that they take in too much, would not anaemia, doctor may find they lack vitamin B12, have delayed treating. But folic acid that take in want up to 1 more than can present this kind of situation every day, according to present folic acid addition level, it is unlikely
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