U.S.A. discovers it is not a smoker that suffers from the relevant gene of lung cancer

U.S.A. discovers it is not a smoker that suffers from the relevant gene of lung cancer
American researchers find, it is not the smoker that suffers from lung cancer and generally correlates with a gene, if this gene morphs, the activity is reduced, suffering from the lung cancer risk may increase.
Discovery this help, study the intersection of lung cancer and target to treat and predict that suffers from the high-risk group of lung cancer further.
Find the key
This kind of gene is called G P C 5. Researcher, medical college of Mayo Clinic, find G P C 5 gene morph, may it makes to be smoker suffer from risk of lung cancer increase.
It is not smokers that researchers choose 754, drew their DNA (D N A) The sample, analyze over 30 ten thousand D N A variants among them, it is not the genetic mutation that the smoker suffered from the probability of lung cancer to study influence.
After considering age, gender, race, chronic breathing problem history of the research object, sucking second hand cigarette quantity and ill history of lung cancer of family synthetically, researchers find, two pieces of genome play a key role.
Confirm the gene
Researchers find out 44 most general genetic mutations from first group of D N A samples, it is not these genetic mutations of the smoker's to observe other two groups again. Half the persons have already made a definite diagnosis of the lung cancer patient in these two groups of research objects.
Found finally, the same two pieces of genome were the key point, they were responsible for " L Open " R Sum " L Close " G P C 5 genes.
Researcher discover compared with healthy people's lung, lung the intersection of gland and cancer G P C 5 genetic activity of patient low 5,000 further. Lung gland cancer is a kind of most common lung cancer .
Researcher think G P C 5 activity might cause it is smoker that suffer from lung cancer while being low in view of the above, expected through further studying this gene, research and develop the lung cancer target to the new method of treatment, and distinguish that suffers from the high-risk group of lung cancer.
This confirms some piece of particular genetic influence is not that the smoker suffer from the lung cancer risk for the first time. This result Publish on on the 22nd >Network edition of the magazine . This magazine reports, 1/4 are not a smoker in the global lung cancer patient.
Await deepening
Some experts think, need further studying such related reason.
American Washington University School of Medicine draws Maass and Wami Dr. Ge WenDan is here>The magazine publishes the comment and says, the distance utilizes this result of study to predict that suffer from the high-risk group of lung cancer to return comparison " Remote " .
" Come from not smoking preliminary observation of the history crowd's tumour sample as to these, need further studying and confirming, " R He says.
Scientific message department executive Carter of research association of Britain cancer A holds the same opinion in Nicaragua . BBC (B B C) Quote him report 22, though British lung cancer patient of 90 come from smoking, but not that still considerable that the smoker suffers from the number of this disease.
He says : " L These new results of study might help to explain ' It is not that the smoker suffers from lung cancer) Reason, need, carry on more research, precise to explain genetic mutation these how about produce, get in touch with the lung cancer risk. "
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