U.S.A. discovers : Cocaine will influence the gene expression of the brain

U.S.A. discovers : Cocaine will influence the gene expression of the brain
American researchers find, taking in cocaines for a long time will change the expression way of the gene in the brain. This discovery is by newest U.S.A. >The magazine publishes, perhaps contribute to formulating the method of giving up taking addictive drugs more effectively.
Obtain pleasant sensation
The research report is asserted, cocaine Israel " L Histone methyl " R The course influences the apparent heredity of the gene in the brain, namely influence gene expression on condition that change gene sequence.
Report announce in the brain having one enzyming, for control with the intersection of pleasant sensation and relevant gene " L The switch " . Taking in cocaines will cause this kind of enzyme for a long time " L Fail " ,And then make people obtain pleasant sensation according to cocaine.
Abuse narcotic director of research institute Nora and Wal and do in the test and is thought in the whole country of U.S.A., this result of study can help to explain how cocaines change the brain function. Reuter Invoke the report that Wal does in the test on the 8th : " This discovery lets us understand better cocaine become how the addiction will exert a long-term influence on nervous function. "
Become reliance
Researchers study the difference of taking in cocaine and disposable absorption cocaine for a long time through animal's experiment: Inject cocaines continuously for a group of little mice; And inject the brine continuously, injects a cocaine for them only at the end of experiment for another group of little mice.
The experimental result reveals, the little mouse taking in cocaine for a long time produces dependence to cocaine; Their gene expression course significantly changes . The similar situation has appeared in other experiments before .
Researchers find, as changing in the brain " L The pleasant sensation centre " R One of the function ways, cocaine inhibits one kind from being called " Gallium " Gene expression. This kind of gene can produce an enzyme, in order to control the expression of some other kinds of genes.
Urge to treat
Researcher's first discovery, " L Reverse " R Cocaine is inhibited " Gallium " The course of gene expression, can suspend the change of gene expression, reduce becoming the addiction of cocaine.
" This important discovery makes us study cocaine into the addiction and make progress, " Wal does in the test and says, " L Though also need further studying, we have already announced that take in a key ring in the chain reaction of molecule that cocaines brings out for a long time. By this, we may formulate the new method to rehabilitate addicts. "
Endure the mountain brain director of research institute Eric of medical college in the west of U.S.A. Nest ties tight and says : " With proning to to taking in the research of the gene and apparent hereditary course due to cocaine for a long time overallly, we understand the biochemical regulation mechanism of the whole brain further too. "
" Other routes to influence the brain that this not merely contributes to studying cocaines, " He says, " L Contribute to, find the new one even ' Give up taking addictive drugs) Treatment means. "
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